1
It has been reported that pulmonary surfactants or their components could facilitate the uptake of small interfering RNA (siRNA) into the lung epithelial cells.
1
Secretion of pulmonary surfactant in the alveoli of the lungs is essential to maintain lung function.
2
Mixtures of PxB and pulmonary surfactant show antimicrobial effects in neonatal rabbits and prevent systemic spreading of E. coli.
3
In neonatal pneumonia, the surface activity of pulmonary surfactant is impaired and microorganisms may invade by passing the air-liquid interface.
4
Recent studies have demonstrated that pulmonary surfactant protein (SP)-A plays a potential role in modifying inflammation and immune function.
5
However, it is vital that corticosteroids delivered via the lungs not interfere with surface activity of the pulmonary surfactant lining layer.
1
Therefore, the gas transfer characteristics of lung surfactant film are of fundamental physiological interest.
2
The experimental results suggest that lung surfactant plays a role in oxygen transfer in the pulmonary system.
3
In addition to their effects on alveolar surface tension, some components of lung surfactant also have immunological functions.
4
The source of FA in the lung is believed to be phosphatidylcholine, the major component of lung surfactant.
5
The mechanism by which lung surfactant achieves very low near-zero surface tensions, well below its equilibrium value, is not fully understood.
6
We found recently that the hydrophobic lung surfactant protein SP-C specifically binds to the lipid A region of lipopolysaccharide (LPS).
7
This research studies the biophysical surface activity of synthetic phospholipids combined in vitro with purified lung surfactant apoprotein, having an Mr of 6000.
8
The squeeze-out process follows a nucleation-growth model and only occurs within a narrow surface pressure range around the equilibrium spreading pressure of lung surfactant.
9
The current study provides evidence that sequence-random copolymers can mimic the in vitro surface-active behavior of lung surfactant proteins in a mixed lipid film.
10
Previously, LPCAT1 has been suggested to be critical for the production of lung surfactant phospholipids and biosynthesis of platelet-activating factor in noninflammatory remodeling pathway.
11
The Michigan team modeled an unhealthy lung by using liquid that was missing lung surfactant, which normally reduces surface tension in the bronchial tubes.
12
Biophysical studies of the CLSE replacement surfactant containing only SAP 6-14 and native phospholipids demonstrated full surface activity compared to natural lung surfactant.
13
This study emphasizes the crucial functional activity of SP-B in lung surfactants.